What is the best chess opening according to Stockfish?

According to Stockfish 16 with a search depth of 75 (ELO > 3000), the best opening is : 1. e4 (e2e4)

This first move give an advantage to the white of 15 centipawns.

The full optimal opening is the following (Ruy López Opening):

1. e4 e5
2. Nf3 Nc6
3. Bc4 Bc5
4. d3 a6

The seven Stockfish best first moves are:

1. e4 (e2e4) 15 centipawns
2. d4 (d2d4) 8 centipawns
3. ♘f3 (g1f3) 4 centipawns
4. e3 (e2e3) 3 centipawns
5. c4 (c2c4) 0 centipawn
6. g3 (g2g3) 0 centipawn
7. c3 (c2c3) 0 centipawn

Here is the full Stockfish output with a depth of 75:

info depth 75 seldepth 86 multipv 1 score cp 15 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv e2e4 e7e5 g1f3 b8c6 f1c4 f8c5 d2d3 a7a6 e1g1 d7d6 c2c3 g8f6 f1e1 e8g8 h2h3 h7h6 b1d2 c6a5 b2b4 a5c4 b4c5 c4d2 d1d2 d6c5 f3e5 f8e8 f2f4 b7b5 d2c2 c5c4 d3c4 c8b7 c4b5 a6b5 c2b3 b7e4 b3f7 g8h8 c1e3 d8d5 f7d5 e4d5 a2a3 h8g8 g1h2 f6e4 e3d4 c7c5 d4g1 a8a4 e5d7 d5c6 d7c5 e4c5 g1c5 a4f4 e1e8 c6e8 a1e1 e8c6 e1e6 f4f6 e6e7 f6f7 e7e5 f7f6 c5d4 g8f7 e5c5 f6e6 g2g4 g7g5 c5f5 f7e7 h2g3 c6e8 d4g7 e7d6 g7f8 d6c7 f5f2 e8c6 g3h2 c6d7

info depth 75 seldepth 86 multipv 2 score cp 8 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv d2d4 g8f6 g1f3 d7d5 c2c4 e7e6 b1c3 c7c5 c4d5 c5d4 d1d4 e6d5 c1g5 f8e7 e2e3 e8g8 d4a4 h7h6 g5h4 b8c6 f1b5 f6e4 h4e7 c6e7 e1g1 e4c3 b2c3 c8f5 b5e2 d8c7 a1c1 e7c6 f1d1 f8d8 f3d4 f5e4 d4c6 b7c6 e2d3 e4d3 d1d3 a8b8 d3d4 b8b2 g2g3 a7a5 h2h4 c7b6 c1d1 b6c5 c3c4 b2b4 a4c2 d8b8 d1c1 b4c4 d4c4 d5c4 c2c4 c5c4 c1c4 b8b2 c4a4 b2b5 g1g2 g8f8 g2f3 f8e7 g3g4 e7d6 f3e4 f7f6

info depth 75 seldepth 79 multipv 3 score cp 4 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv g1f3 d7d5 d2d4 g8f6 c2c4 e7e6 g2g3 f8b4 c1d2 b4e7 f1g2 c7c6 e1g1 e8g8 d1c2 b8d7 d2f4 b7b6 c4d5 c6d5 f1c1 c8b7 c2b3 a8c8 c1c8 d8c8 b1c3 f6h5 f4g5 e7g5 f3g5 h5f6 g2f1 h7h6 g5f3 c8a8 b3a3 a7a6 a1c1 f8c8 e2e3 f6e4 c1c2 c8c7 f3e1 a8f8 a3f8 g8f8 c3d1 c7c2 e1c2 e4d6 f1d3 f8e7 f2f3 d7b8 g1f1 b6b5 b2b3 f7f5 d1c3 b8d7

info depth 75 seldepth 84 multipv 4 score cp 3 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv e2e3 g8f6 g1f3 d7d5 d2d4 c7c5 f1e2 e7e6 e1g1 b8c6 d4c5 f8c5 a2a3 e8g8 b2b4 c5d6 c1b2 e6e5 c2c4 d5c4 b1d2 b7b5 a3a4 c8a6 a4b5 a6b5 e2c4 a7a6 d1b1 d8e7 h2h3 a8c8 f1c1 c6b4 b2e5 d6e5 f3e5 e7e5 b1b4 b5c4 d2c4 e5e6 c4d2 c8c1 a1c1 h7h6 c1a1 f8a8 d2f1 e6e4 b4c3 e4b7 f1g3 f6e4 g3e4 b7e4 c3c7 e4e8 a1a5 e8b8 c7b8 a8b8 a5a6 g7g6 a6a2 g8g7 g1h2 b8c8 a2a7 g6g5

info depth 75 seldepth 68 multipv 5 score cp 0 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv c2c4 e7e5 g2g3 d7d5 c4d5 g8f6 b1c3 f6d5 f1g2 d5b6 g1f3 b8c6 d2d3 f8e7 e1g1 e8g8 a2a3 f8e8 c1e3 e7f8 c3e4 a7a5 e3b6 c7b6 e4c3 c8e6 e2e3 h7h6 f1e1 g7g6 d3d4 e5d4 f3d4 c6d4 e3d4 d8d7 h2h4 e6g4 d1d3 f8g7 d4d5 a8d8 g1h2 d7d6 c3e4 d6e5 d3b5 e5b2 e4f6 g7f6 e1e8 d8e8 b5e8 g8g7 a1e1 b2a3 e8b8 a3b2 e1e8 b2f2 e8h8 f6d4 b8f8 g7f6 f8d8 f6g7 d8f8

info depth 75 seldepth 68 multipv 6 score cp 0 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv g2g3 e7e5 c2c4 d7d5 c4d5 g8f6 b1c3 f6d5 f1g2 d5b6 g1f3 b8c6 d2d3 f8e7 e1g1 e8g8 a2a3 f8e8 c1e3 e7f8 c3e4 a7a5 e3b6 c7b6 e4c3 c8e6 e2e3 h7h6 f1e1 g7g6 d3d4 e5d4 f3d4 c6d4 e3d4 d8d7 h2h4 e6g4 d1d3 f8g7 d4d5 a8d8 g1h2 d7d6 c3e4 d6e5 d3b5 e5b2 e4f6 g7f6 e1e8 d8e8 b5e8 g8g7 a1e1 b2a3 e8b8 a3b2 e1e8 b2f2 e8h8 f6d4 b8f8 g7f6 f8d8 f6g7 d8g8

info depth 75 seldepth 38 multipv 7 score cp 0 nodes 4212582317731 nps 25879005 hashfull 1000 tbhits 0 time 162779913 pv c2c3 e7e5 d2d4 e5e4 c3c4 c7c6 c1f4 f8b4 b1c3 d7d5 e2e3 g8e7 f4g3 e8g8 a1c1 c8e6 c4d5 e7d5 g1e2 b8d7 a2a3 b4c3 e2c3 d5c3 c1c3 e6d5 f1e2 f7f5 a3a4 a7a5 b2b3 f8f7 d1d2 d8e7 e2h5 f7f8 h5e2

bestmove e2e4 ponder e7e5